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Accueil > Archives > Articles Scientifiques > Polysaccharides > Genre Streptococcus

Determination of native capsular polysaccharide structures of Streptococcus pneumoniae serotypes 39,42 and 47F

par Emmanuel Maes - publié le

by : Petersen B. O., Meier S., Smestad Paulsen B., Redondo A. R. and Skovsted I. C. (2014), Carbohydrate Research, 395, 38-46

ABSTRACT

The diversity of capsular polysaccharides of the bacterial pathogen Streptococcus pneumoniae leads to at least 91 different serotypes. While the genetic loci for capsular biosynthesis have been characterized for all serotypes, the determination of resultant polysaccharide structures remains incomplete.
Here, we report the chemical structures of the capsular polysaccharides of serotypes 39, 42, and 47F from the genetic cluster 4, and discuss the structures in the context of structures from serologically and genetically related serotypes. Antigenic determinants can be approximated in this manner.